Metabolite Control of L - Fucose Utilization 8361
نویسندگان
چکیده
Thyroid fucokinase is responsive to a number of metabolites which might serve in a regulatory capacity. In addition to inhibition by ADP and stimulation by GMP, fucokinase responds selectively to a series of nucleotide sugars. Of those studied, only guanine nucleotide sugars moderate the activity of the enzyme. GDP-a-D-mannose, GDP-a-D-glucose, GDP-cY-D-rhamnose, and GDP-cu-L-rhamnose all stimulate fucokinase activity. GDP-/3-L-fucose on the other hand is strongly inhibitory. In the case of GDP-cx-D-mannose stimulation, a physiological role seems possible, but the rationale is not entirely clear. The effects of GDP-P-L-fucose, on the other hand, may represent physiological control effected through feedback inhibition by an end product.
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